A synthetic decapeptide bradykinin B2 receptor antagonist for on-demand treatment of acute HAE attacks.

A cyclic lipopeptide antibiotic discovered in 1947, dropped from common use in the 1970s due to toxicity, and resurrected in the 2000s as one of…

Enfuvirtide is a 36-amino acid synthetic peptide and the first member of the class of HIV entry inhibitors, specifically a fusion inhibitor. It was developed…

Thymosin alpha-1 (Tα1) is a 28-amino acid peptide fragment derived from the larger precursor protein prothymosin alpha. It was first isolated from bovine thymus tissue…

Romidepsin is a potent bicyclic depsipeptide and a selective inhibitor of histone deacetylases (HDACs), specifically Class I HDACs (1, 2) and Class IIb (HDAC6). It…

Carfilzomib is a second-generation, selective, and irreversible proteasome inhibitor. It is a synthetic analog of the natural product epoxomicin, optimized for improved pharmacological properties. The…

Pegcetacoplan is a synthetic, pegylated peptide designed as a targeted inhibitor of complement C3. It is derived from a fragment of the human complement C3…

Bivalirudin is a synthetic, bivalent direct thrombin inhibitor peptide. It was rationally designed based on the structure of hirudin, the potent natural thrombin inhibitor found…

Eptifibatide is a synthetic, cyclic heptapeptide and a potent, reversible antagonist of the platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptor, also known as integrin αIIbβ3. It was…

Substance P is an 11-amino acid neuropeptide belonging to the tachykinin family. It was first discovered in 1931 by Ulf von Euler and John H.…